Drosophila β1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids
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چکیده
منابع مشابه
Blood group A active glycoproteins of respiratory mucus and their synthesis by an N-acetylgalactosaminyltransferase.
An N-acetylgalactosaminyltransferase has been found in canine respiratory tissue which catalyzes the transfer of GalNAc from UDP-GalNAc to a blood group H substance with the formation of a substance with human blood group A activity. The transfer was dependent upon Mn2+ and was stimulated several fold by Triton X-100. The optimal pH was between 5 and 6. The approximate K, values for UDP-GalNAc ...
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20 Lin, A. A,, Kimura, R. and Miller, W. M. (1993) Biotechnol. Bioeng. 42, 339-350 Jenkins, N., Castro, 1’. M. I,., Menon, S., Ison, A. P. and Hull, A. T. (1994) Cytotechnology 12, 1-10 James, D. C., Freedman. R. B.. Hoare, M. and Jenkins, N. (1994) Anal. Hiochem. 222.3 15-322 Edge, C. J., Parekh, R. B., Rademacher, T. W., Wormald, M. and Dwek, R. A. (1992) Nature (London) 358.693-694 Sutton, C...
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Polypeptide N-acetylgalactosaminyltransferases (GalNAc-transferases) catalyze the initial reaction of mucin-type O-glycosylation. Here, we report the first biochemical characterization of one of the Drosophila GalNAc-transferases, dGalNAc-T3. This enzyme retains conserved motifs essential for the catalytic activity, but is a novel isozyme in that it has several inserted sequences in its lectin-...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2007
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.01.015